Lakehead University evolved from the Lakehead Technical Institute (LTI), which was established in 1946. From LTI, Lakehead became the Lakehead College of Arts, Science and Technology in 1956. The Lakehead University Act was given Royal Assent by the Lieutenant Governor of Ontario in 1965, and Lakehead University was established. The first degrees granted by Lakehead University were in Arts and Science in 1965.

The Lakehead University fonds includes records of administrative offices and former administrators.